2. Signaling Pathways
  3. Anti-infection
  4. Parasite

Parasite

Parasite

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Antiparasitics are a class of medications which are indicated for the treatment of parasitic diseases such as nematodes, cestodes, trematodes, and infectious protozoa.

Parasite Isoform Specific Products:

Parasite Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-B0508S
    Ornidazole-d5
    		Inhibitor
    Ornidazole-d5 is deuterium labeled Ornidazole. Ornidazole (Ro 7-0207) is a nitroimidazole derivative with anti-trichomonad activity and in vitro activity against a variety of anaerobic bacteria. Ornidazole inhibits Sonic hedgehog (Shh) signaling pathway, exhibits antitumor activity. Ornidazole can be used in research of Crohn’s disease.
    Ornidazole-d<sub>5</sub>
  • HY-121473
    Aklavin
    		Inhibitor
    Aklavin is a structural analog of Aclacinomycin A (HY-N2306) produced by Streptomyces strain A 1165. Aklavin possesses Z-DNA-inducing and stabilizing activities, along with antibiotic, anti-phage and broad-spectrum antimicrobial activities. Aklavin inhibits the proliferation of various viruses (such as influenza virus and poliovirus) and interferes with their nucleoprotein synthesis, while also exhibiting inhibitory effects on staphylococci, mycobacteria and specific fungi. Aklavin blocks phage-induced bacterial lysis by regulating host-parasite interactions. Aklavin shows specific toxicity to fertilized eggs and mice, and does not alter the splicing of the SMN2 gene.
    Aklavin
  • HY-B1607A
    Chlorphenoxamine hydrochloride
    		Inhibitor
    Chlorphenoxamine hydrochloride, an antihistamine and anticholinergic agent is a GPCR antagonist. Chlorphenoxamine hydrochloride inhibits multiple lethal viral diseases, such as SARS-CoV, MERS-CoV, EBOV and malaria. Chlorphenoxamine hydrochloride shows anti-filovirus activity against both EBOV and Marburg virus (MARV) with IC50s of 1.1 μM and 6.2 μM, respectively. Chlorphenoxamine hydrochloride is used for allergic conditions, urticaria, viral diseases and Parkinson’s disease.
    Chlorphenoxamine hydrochloride
  • HY-128398
    CpCDPK1/TgCDPK1-IN-2
    		Inhibitor
    CpCDPK1/TgCDPK1-IN-2 (Compound 7r) is a CpCDPK1 and TgCDPK1 inhibitor with IC50 values of 12 and 5 nM, respectively. CpCDPK1/TgCDPK1-IN-2 can be used in the research of apicomplexan protozoa-related diseases, such as the research of T. gondii, C. parvum and C. hominus infection.
    CpCDPK1/TgCDPK1-IN-2
  • HY-137034
    (+)-Secolongifolene-diol
    (+)-Secolongifolene-diol is a sesquiterpene, that can be isolated from the marine fungal Drechslera sp. (+)-Secolongifolene-diol exhibits slightly weak effectiveness in antioxidation, antimicrobial and antifouling aspects.
    (+)-Secolongifolene-diol
  • HY-149073
    TSC26
    		Inhibitor
    TSC26, a thiosemicarbazone, is a potent cruzipain (CZP) inhibitor with an IC50 of 175 nM, a pIC50 of 6.76 and a pKa of 6.6. TSC26 has the potential for parasitic diseases research.
    TSC26
  • HY-135666
    DHODH-IN-8
    		Inhibitor
    DHODH-IN-8 (Compound 27) is an inhibitor of human and Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) with IC50s of 0.13 μM and 47.4 μM, and Kis of 0.016 μM and 5.6 μM, respectively. DHODH-IN-8 has antimalarial activity.
    DHODH-IN-8
  • HY-W099569
    Zinc stearate
    		Inhibitor
    Zinc stearate is a metal stearate that acts as a preservative, bactericide, fungicide, and larvicide. Zinc stearate inhibits larval reproduction in animal feces. Zinc stearate exhibits extremely low systemic toxicity. Zinc stearate is a common component of pharmaceutical excipients, lubricants, mold release agents, polymer stabilizers, and coating matting agents.
    Zinc stearate
  • HY-158721
    Penicinoline
    		Inhibitor
    Penicinoline (Marinamide) (Compound 1), a pyrrolyl 4-quinolinone alkaloid, is a microbial secondary metabolite. Penicinoline can be isolated from endophytic fungus Penicillium sp. Penicinoline has antimalarial activity against Chloroquine (HY-17589A) sensitive strain (pf3d7) and against Chloroquine resistant strain (pfDd2) of plasmodium falciparum. Penicinoline also has strong insecticidal activity against Aphis gossypii and selective anticancer effect with significant cytotoxicity for 95-D and HepG2 cells.
    Penicinoline
  • HY-N1219
    Stephanine
    		Inhibitor
    Stephanine ((-)-Stephanine) is an isoquinoline aporphine-type alkaloid. Stephanine induce apoptosis through the reverse of mitotic exit. Stephanine exhibits Antiplasmodial activity. Stephanine can be used for the research of stomach pain, abdominal pain, arthritis and cancer.
    Stephanine
  • HY-W842297
    Epiquinine
    		Inhibitor
    Epiquinine is a stereoisomer of Quinine (HY-D0143). Epiquinine exhibits activity against chloroquine-sensitive and chloroquine-resistant Plasmodium falciparum parasites. Epiquinine can be used for the research of malaria.
    Epiquinine
  • HY-121154
    Hexachloroparaxylene
    Hexachloroparaxylene could be used in the study of in fascioliasis in swine.
    Hexachloroparaxylene
  • HY-155025
    Antitrypanosomal agent 14
    		Inhibitor
    Antitrypanosomal agent 14 (Compound 1) is a T. brucei inhibitor (EC50: 0.47 μM). Antitrypanosomal agent 14 inhibits TbGSK3 with an IC50 of 12 μM. Antitrypanosomal agent 14 can be used for the research of Human African trypanosomiasis.
    Antitrypanosomal agent 14
  • HY-134199
    IMP-1002
    		Inhibitor
    IMP-1002 is a Plasmodium N-myristoyltransferase (NMT) inhibitor. IMP-1002 inhibits myristoylation activity, blocks parasite development. IMP-1002 can be used for the research of malaria.
    IMP-1002
  • HY-168429
    3HKT-IN-1
    		Inhibitor
    3HKT-IN-1 (Compound 17122279) is an Anopheles gambiae 3-hydroxykynurenine transaminase (3HKT) inhibitor. 3HKT-IN-1 can be used for Malaria research.
    3HKT-IN-1
  • HY-N16388
    α-Costic acid
    		Inhibitor
    α-Costic acid is a plant sesquiterpene that can induce oxidative stress and autophagy in tomatoes. α-Costic acid has acaricidal activity.
    α-Costic acid
  • HY-146049
    Antitrypanosomal agent 4
    		Inhibitor
    Antitrypanosomal agent 4 (compound 19) is a potent and blood-brain barrier permeable antitrypanosomal agent. Antitrypanosomal agent 4 has good activity against Trypanosoma cruzi (T. cruzi) and Trypanosoma brucei brucei (T. b. brucei) with IC50s of 1.2 μM and 70 nM, respectively. Antitrypanosomal agent 4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Antitrypanosomal agent 4
  • HY-121187
    BiPNQ
    		Inhibitor
    BiPNQ is a potent inhibitor of Trypanosoma cruzi, the causative agent of Chagas disease.
    BiPNQ
  • HY-115364S
    Parbendazole-d3
    		Inhibitor
    Parbendazole-d3 is the deuterium labeled Parbendazole. Parbendazole is a potent inhibitor of microtubule assembly, destabilizes tubulin, with an EC50 of 530 nM, and exhibits a broad-spectrum anthelmintic activity.
    Parbendazole-d<sub>3</sub>
  • HY-137141
    16-Keto Aspergillimide
    		Inhibitor
    16-Keto Aspergillimide (SB202327) is an anthelmintic agent isolated from Aspergillus strain IMI 337664.
    16-Keto Aspergillimide
Parasite Isoform Comparison

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